In Plesk v12 or newer, mail can be disabled on a per-domain basis via the Plesk interface. Go to Mail tab -> Change Settings
For Plesk ≤11.5, mail service can be disabled for an entire subscription via Mail tab -> Change Settings -> uncheck "Activate mail service on domain", or for an individual domain via command line:
Linux (CentOS):
/usr/local/psa/bin/domain -u example.com -mail_service false
Windows:
"%plesk_bin%\mailmng.exe" --turn-off-domain --domain-name=example.com